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Delays can occur in any phase of the study, including patient enrollment, analysis of study results, or submission of the final study report to the FDA.
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Since treatment halts progression of disease in those who already have clinical manifestations and prevents disease manifestations in those already infected or those not yet infected, we assumed that treatment is completely effective in eliminating the risk of morbidity due to onchocerciasis among treated individuals.
These arise from a number of features of biological systems, including thresholds such as developmental or behavioral temperature thresholds, discontinuities at the edges of the ranges of species, nonlinear responses to temperature and moisture, multiplicative effects of population growth in vectors with multiple generations each year, negative feedback associated with competition or predation as population densities increase, interactions between variables resulting in nonadditive effects, and the disproportionate effects of changes in the frequency of extreme events with small changes in the value of the mean.
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In 1998, MSD expanded the MSD MECTIZAN Donation Program to include the prevention of lymphatic filariasis (LF), commonly referred to as elephantiasis, in African countries where the disease co-exists with river blindness.
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Some GCMs were indicating increases, while others gave opposite results, and the directions also changed in summer and winter.
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CCB written for the fifth Global Health Promotion conference in Mexico (), a major American conference on the topic (), a comprehensive Canadian report on CCB measurement (), a technical report written last year for WHO on CCB and community mobilization (), a forthcoming WHO report on empowerment and health promotion () and various books on theory and practice (e.
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The key measures that are needed to reduce the vulnerability of different communities around the world, by managing the impacts of each global change driver are as follows.
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As a result of the investments and work of many partners, the efforts toward control and elimination of both Onchocerciasis and LF are advancing.
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As a result, the WHO is increasing its efforts to target noncommunicable diseases around the world.
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Acceleration of the reduction in transmission can be achieved either by improving the implementation of annual CDTI, notably increasing CDTI treatment coverage, or by using alternative treatment strategies (ATS) where CDTI cannot be implemented effectively (in particular in areas co-endemic for loiasis), or CDTI effectiveness is considered sub-optimal.
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